IUBMB Virtual Issue on Diabetes

Diabetes Mellitus: A Bitter Disease with a Sweet Name – An IUBMB Journals Joint Virtual Issue

Edited by IUBMB Journals Editors-in-Chief Drs. Angelo Azzi, Gianfranco Gilardi,Phillip Ortiz, William Whelan , and Jian-Jiang Zhong.

Diabetes, either type 1 diabetes which is due to poor insulin release, or type 2 diabetes which is the consequence of ineffective use of insulin, is one of the most significant challenges to human health. The increased blood and urine glucose (hence the name mellitus, sweet) is a major cause of cardiovascular disease, adult blindness, non-traumatic amputation and end stage kidney failure. In addition, it is believed to increase the danger of neurocognitive loss and frailty and is associated with an increased frequency of most forms of cancer. Therefore, its economic effects are enormous. The current global occurrence of diabetes is ~ 9% among adults, and it is the 7th leading cause of death.

Such a global occurrence requires a comprehensive approach, necessary to understand the molecular aspects of the disease which can be translated into prevention and therapies.The four IUBMB journals represent an overarching way of spreading basic scientific research as well as stimulating education and fundamental technological innovation in the field. The articles collected in this virtual issue have been published during the last two years in IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education: they exemplify the contribution of basic and technological researches as well as education to the solution of such a global threaten to human health, diabetes.It is our pleasure to present them in this compendium as we hope it will lead to a greater awareness of the efforts of our scientific community in dealing with this disease and that you will use these articles in your research and teaching.


The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling

Alexander M. Scherbakov, Danila V. Sorokin, Victor V. Tatarskiy Jr., Nikolay S. Prokhorov, Svetlana E. Semina, Lev M. Berstein, Mikhail A. Krasil'nikov. DOI: 10.1002/iub.1481

Circulating serum irisin levels in obesity and type 2 diabetes mellitus 

Amira Shoukry, Sally M. Shalaby, Shereen El-Arabi Bdeer, Amira A. Mahmoud, Mayada M. Mousa, Ashraf Khalifa. DOI: 10.1002/iub.1511

Biphasic decline of ß-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onset

Sirlene R. Cechin, Omar Lopez-Ocejo, Darla Karpinsky-Semper and Peter Buchwald. DOI: 10.1002/iub.1391

Type-2 diabetes: Current understanding and future perspectives

Ankita Pandey, Sheetal Chawla and Prasenjit Guchhait. DOI: 10.1002/iub.1396

Fructosylation generates neo-epitopes on human serum albumin

Shaziya Allarakha, Parvez Ahmad, Mohd Ishtikhar, Mohammad Shoaib Zaheer, Sheelu Shafiq Siddiqi, Moinuddin and Asif Ali. DOI: 10.1002/iub.1375

Antidiabetic activity of Sedum dendroideum: Metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin

Daniel Da Silva, Livia Marques Casanova, Mariah Celestino Marcondes, Jair Machado Espindola-Netto, Larissa Pereira Paixão, Giany Oliveira De Melo, Patricia Zancan, Mauro Sola-Penna and Sônia Soares Costa. DOI: 10.1002/iub.1270

Cells producing their own nemesis: Understanding methylglyoxal metabolism

Sangeeta Chakraborty, Kapudeep Karmakar and Dipshikha Chakravortty. DOI: 10.1002/iub.1324


Effects of n-3 pufas on fasting plasma glucose and insulin resistance in patients with impaired fasting glucose or impaired glucose tolerance

Giuseppe Derosa, Arrigo F.G. Cicero, Angela D'Angelo, Claudio Borghi, Pamela Maffioli. DOI: 10.1002/biof.1277

Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice 

Pragyanshu Khare, Sneha Jagtap, Yachna Jain, Ritesh K. Baboota, Priyanka Mangal, Ravneet K. Boparai, Kamlesh K. Bhutani, Shyam S. Sharma, Louis S. Premkumar, Kanthi K. Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi. DOI: 10.1002/biof.1265

Curcumin and insulin resistance—Molecular targets and clinical evidences

Angélica Saraí Jiménez-Osorio, Adriana Monroy, Silvestre Alavez. DOI: 10.1002/biof.1302

Branched-chain amino acids supplementation protects streptozotocin-induced insulin secretion and the correlated mechanism

Ming Lu, Xiujuan Zhang, Dongmei Zheng, Xiuyun Jiang and Qing Chen. DOI: 10.1002/biof.1188

Retinol binding protein-4 predicts incident diabetes in Asian Indian men with prediabetes

Jagannathan Ram, Chamukuttan Snehalatha, Sundaram Selvam, Arun Nanditha, Ananth Samith Shetty, Ian F. Godsland, Desmond G. Johnston and Ambady Ramachandran. DOI: 10.1002/biof.1209

Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico

Chien-Hung Jhong, Jirawat Riyaphan, Shih-Hung Lin, Yi-Chen Chia and Ching-Feng Weng. DOI: 10.1002/biof.1219

Ascorbic acid efflux from human brain microvascular pericytes: Role of re-uptake

James M. May and Zhi-Chao Qu. DOI: 10.1002/biof.1227

Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo

Byung Geun Ha, Takayuki Yonezawa, Myoung Jin Son, Je Tae Woo, Shinsuke Ohba, Ung-Il Chung and Kazumi Yagasaki. DOI: 10.1002/biof.1165

Biotechnology and Applied Biochemistry

Human umbilical cord–derived mesenchymal stem cells can secrete insulin in vitro and in vivo

Zahra Niki Boroujeni and Ahmad Aleyasin. DOI: 10.1002/bab.1127

Identification and analysis of novel R308K mutation in glucokinase of type 2 diabetic patient and its kinetic correlation

Nanda Kumar Yellapu, Koteswara Rao Valasani, Santhosh Kumar Pasupuleti, Sowjenya Gopal, Sarma Potukuchi Venkata Gurunadha Krishna and Bhaskar Matcha. DOI: 10.1002/bab.1209

The preservation of islet with alginate encapsulation in the process of transportation

Na Li, Ying Zhang, Zhilong Xiu, Yu Wang, Li Chen, Shujun Wang, Shen Li, Xin Guo and Xiaojun Ma. DOI: 10.1002/bab.1295

Biochemistry and Molecular Biology Education

Comprehensive experiment—clinical biochemistry: Determination of blood glucose and triglycerides in normal and diabetic rats

Li Jiao, Shi Xiujuan, Wang Juan, Jia Song, Xu Lei, Xu Guotong and Lu Lixia. DOI: 10.1002/bmb.20836

Oxidative damage in diabetics: Insights from a graduate study in La Reunion University

Dorothée Girard, Philippe Rondeau, Aurélie Catan, Cynthia Planesse, Pierre Giraud and Emmanuel Bourdon. DOI: 10.1002/bmb.20818

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