IUBMB Virtual Issue on Aging

Aging: A Condition None of Us Can Escape – An IUBMB Journals Joint Virtual Issue

Edited by IUBMB Journals Editors-in-Chief Drs. Angelo Azzi, Gianfranco Gilardi, Phillip Ortiz, William Whelan and Jian-Jiang Zhong.

Aging is a natural and irreversible process of growing older. In 2010, 8% of the world’s population or 524 million people were elderly people over 65 years of age. By 2050, the number is expected to rise to 16%. Increasing senescence is associated with increasing frequency of aging-associated diseases, such as atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, neurodegenerative disorders including Alzheimer’s disease, diabetes, and many others. Combined with a growing number of older people, the economic effects of the aging populations are significant, requiring a renewed approach to secure them financially, and to provide them with the adequate health and social care.

Many of aging-associated diseases can be managed effectively by prevention, early diagnosis, and right therapies. The four IUBMB journals represent an overarching way of spreading basic scientific research as well as stimulating education and fundamental technological innovation in the field. The articles collected in this virtual issue have been published during the last three years in IUBMB Life, BioFactors, Biotechnology and Applied Biochemistry, and Biochemistry and Molecular Biology Education: they exemplify the contribution of basic and technological researchers as well as education to the solution of such a global trend. It is our pleasure to present them in this compendium as we hope it will lead to a greater awareness of the efforts of our scientific community in dealing with the aging humankind and that you will use these articles in your research and teaching.

Anti-senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cells

Youn Seo Oh, Sin-Gu Jeong, Goang-Won Cho. Biotechnology and Applied Biochemistry. DOI: 10.1002/bab.1393


Lycopene powers the inhibition of glycation-induced diabetic nephropathy: A novel approach to halt the AGE-RAGE axis menace 

Shams Tabrez, Khalid Zaki Al-Shali, Ahmad Saheem. BioFactors. DOI: 10.1002/biof.1238


Recent advances in detection of AGEs: Immunochemical, bioanalytical and biochemical approaches

Jalaluddin Mohd. Ashraf, Saheem Ahmad, Inho Choi, Nashrah Ahmad, Mohd. Farhan, Tatyana Godovikova, Uzma Shahab. IUBMB Life. DOI: 10.1002/iub.1450


Pinocembrin Inhibits Matrix Metalloproteinase Expression in Chondrocytes

Dawei Zhang, Bo Huang, Chengjie Xiong, Yue Zhou. IUBMB Life. DOI: 10.1002/ iub.1343


Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis

Vishwa Deepak, Marlena C. Kruger, Annie Joubert, Magdalena Coetzee. BioFactors. DOI: 10.1002/biof.1241


Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells

Cheng-Yi Chang, Jian-Ri Li, Yen-Chuan Ou, Wen-Ying Chen, Su-Lan Liao, Shue-Ling Raung, An-Lu Hsiao, Chun-Jung Chen. IUBMB Life. DOI: 10.1002/iub.1434


Guided Inquiry Activities for Learning about the Macro- and Micronutrients in Introductory Nutrition Courses

Andri L. Smith, Rebecca J. Purcell, Joel M. Vaughan. Biochemistry and Molecular Biology Education. DOI: 10.1002/bmb.20913


Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging

Shampa Ghosh, Jitendra Kumar Sinha, Manchala Raghunath. IUBMB Life. DOI: 10.1002/iub.1532


Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice

Remya Sreedhar, Vijayasree V. Giridharan, Somasundaram Arumugam, Vengadeshprabhu; Palaniyandi, Suresh S. Karuppagounder, Prasanna Krishnamurthy, Joao Quevedo, Kenichi Watanabe, Tetsuya Konishi, Rajarajan A. Thandavarayan. BioFactors. DOI: 10.1002/biof.1280


Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy

Juan E. Puche, Ursula Munoz, Mariano Garcia-Magarino, Maria C. Sadaba, Inma Castilla-Cortazar. BioFactors. DOI: 10.1002/biof.1255


Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis

Shi, Jie; Zhang, Changjie; Yi, Zhongjie; Lan, Chunna. Biotechnology and Applied Biochemistry. DOI: 10.1002/bab.1319


Forxiga (dapagliflozin): Plausible role in the treatment of diabetes-associated neurological disorders

Sibhghatulla Shaikh, Syed Mohd. Danish Rizvi, Shazi Shakil, Sania Riyaz, Deboshree Biswas, Roshan Jahan. Biotechnology and Applied Biochemistry. DOI: 10.1002/bab.1319


Dietary beta-carotene and lutein metabolism is modulated by the APOE genotypein silico

Patricia Huebbe, Jennifer Lange, Georg Lietz, Gerald Rimbach. BioFactors. DOI: 10.1002/biof.1219


Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages

Barbara Marengo, Francesca Bellora, Roberta Ricciarelli, Chiara De Ciucis, AnnaLisa Furfaro, Riccardo Leardi, Renata Colla, Davide Pacini, Nicola Traverso, Alessandro Moretta, Maria Adelaide Pronzato, Cristina Bottino, Cinzia Domenicotti. BioFactors. DOI: 10.1002/biof.1243


When Proteostasis Goes Bad: Protein Aggregation in the Cell

Mona Radwan, Rebecca J. Wood, Xiaojing Sui, Danny M. Hatters. IUBMB Life. DOI: 10.1002/iub.1597

Publish with IUBMB

IUBMB journals feature the latest high quality articles, reviews, communications, laboratory exercises, and more in biochemistry and molecular biology. Our editors welcome contributions from authors throughout the world.