Author Guidelines

Note to NIH Grantees. Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see

Copyright Transfer Agreement

Abstracting and Indexing

ADONIS (CD-Rom), Biochemistry & Biophysics Citation Index, Biological Abstracts, BIOSIS database, BIOSIS Previews, CAB Abstracts, CHemical Abstracts, EBSCO'S database, Elsevier BIOBASE/Current Awareness in Biological Sciences, EMBASE/jExcerpta Medica, Immunology Abstracts (CSA), Index Medicus, Current Contents, MANTIS, MasterFILE, Medline/PubMed, Research Alert, SciSearch, SCOPUS.

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BioFactors, a journal of the International Union of Biochemistry and Molecular Biology is devoted to the rapid publication of the most novel and significant original articles and reviews. BioFactors is an international journal aimed at identifying and increasing our understanding of the precise biochemical effects and roles of the large number of substances that are required by living organisms. These include vitamins and trace elements, as well as growth factors and regulatory substances made by cells themselves. The elucidation, in a particular organism or cell line, of the roles of substances active in trace quantities, is frequently applicable directly to many other forms of life.

In keeping with this unified view of biochemistry, BioFactors publishes articles dealing with the identification of new substances and the elucidation of their functions at the basic biochemical level as well as those revealing novel functions of trace substances already known.

All articles are reviewed rapidly by acknowledged experts and, if accepted, are published within about three months. All articles will be published online at

All papers are published on the basis of exceptional scientific merit, originality, and wide biological significance. Manuscripts whose findings are likely to have a lasting impact on experimental biology warrant urgent publication in BioFactors.


The journal to which you are submitting your manuscript employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works.

Manuscripts must be submitted electronically. For complete instructions on how to do so, go to and follow the instructions for creating an account and submitting a manuscript.

When submitting your article to Scholar One Manuscripts, upload as many files as needed for your manuscript. These files will be combined into a single PDF document for the peer review process.

Microsoft Word Format is preferred for manuscript submission. Electronic versions in ASCII or PDF are not acceptable. Each figure must be uploaded separately as an image file using TIFF formatting. Each image file must include all subparts (A, B, C, etc.) to the figure. Subparts should not be uploaded individually. Tables should appear at the end of the manuscript text in the main document and should not be uploaded as separate image files. A figure legend/list of captions should appear at the end of the manuscript text as well. All submissions should have a complete title page and abstract in the main document file.


Research Communications

Research Communications are expected to be complete, original, short studies of broad biological interest. They must present remarkably significant findings that provide new mechanistic understanding of biologically relevant phenomena and their possible connection to human pathology or medicine.

Short Reviews

These papers are concise and focused reviews of topical issues in the biological sciences. They should not be comprehensive of all published literature in a given field but rather represent the author’s creative interpretation of the results in a given scientific area. The length of Short Reviews and their illustrations is not strictly defined and it is left to the authors to make optimal usage of a necessarily limited space.

Review Process

These manuscripts are examined by the editors and to outside referees for critical review. Authors are required to suggest at least four potential reviewers, at least one of whom will often be recruited as a referee. Every effort will be made to provide the corresponding author with an editorial decision within 3 weeks of manuscript receipt. Accepted manuscripts will usually be published in less than 2 months from the date of acceptance.


Contributions should be written concisely in English and should be typed using double-spacing with 30-40 mm margins. All articles should include a brief, informative abstract that will appear at the beginning of the paper. Five to ten keywords should also be included for searching purposes, as well as a running title of less than 60 characters. Authors should familiarize themselves with the style of articles by perusing a recent issue of the Journal.

Data and opinions appearing in the published articles and advertisements are the sole responsibility of the contributor or advertiser concerned. Accordingly, the publishers, the editorial board and editors and their respective employees, officers and agents accept no responsibility or liability for the consequences of published material.

Abbreviations such as those used in the Biochemical Journal ( may be used without definition; other abbreviations should be defined.

Organization and Sub-Headings

Original research articles should generally be organized as follows: Abstract, Introduction, Experimental Procedures, Results, and Discussion. Critical Reviews should begin with an Abstract, followed by an Introduction and by the text of the article.


References should be cited in the text in numerical order in parentheses (e.g. (1) or (1-3)). If a reference is cited more than once the same number should be used each time. References should be numbered in the order of appearance in the manuscript, and compiled in numerical order in a list at the end of the paper. Only published works should be included in the reference list. Unpublished observations, manuscripts in preparation, and personal communications should instead be included in the text. All personal communications or endorsements must be confirmed in writing by the person(s) involved. References of articles with six or more authors should be formatted to include the first five authors followed by et al. Use the following format to reference journals, books, and book chapters.

Journal article

[1] Gal, S., Klein, J. W. (2000) A case for college molecular biology classes: a right to her genes. Biochem. Mol. Biol. Educ. 28, 267-271.


[2] Strunk Jr., W., White, E.B. (1979) The Elements of Style, 3rd ed., Macmillan, New York.

Edited book

[3] Letheridge, S., Cannon, C.R., Eds. (1980) Bilingual Education: Teaching English as a Second Language, Praeger, New York.

Article or chapter in edited book

[4] Gurman, A.S., Kniskern, D.P., in Gurman, A.S., Kniskern, D.P., Eds. (1981) Handbook of Family Therapy, Brunner/Maazel, New York, pp. 742-775.


[5] Chaddock, T.E., in: Daniel, E.E., Ed. (1974) Proceedings of the Fourth International Symposium on Gastrointestinal Motility, Mitchell Press, Vancouver, British Columbia, Canada, pp. 83-92.


[6] Yu, F., Wu, X.-S. (1992) Physics Review Letters 68 2996(hep-th/9112009).


[7] World Index of Molecular Visualization Resources: (revised 2001)

Journal names should be abbreviated according to Chemical Abstracts.

The suggested EndNote reference style can be downloaded here:


All abbreviations used in the text must be defined in a single footnote inserted in the text immediately after the first abbreviation is cited. Abbreviations such as those used in the Biochemical Journal ( may be used without definition; other abbreviations should be defined. The abbreviations of some important biochemical compounds, e.g. ATP, NADH, DNA, and amino acids in proteins, need not be defined.


To ensure the highest quality production, your figures must be submitted in TIFF or JPEG format according to the following minimum resolutions:

  • 1200 dpi (dots per inch) for black and white line art (simple bar graphs, charts, etc.)
  • 300 dpi for halftones (black and white photographs)
  • 600 dpi for combination halftones (photographs that also contain line art such as labeling or thin lines)

Vector-based figures (usually created in Adobe Illustrator) should be submitted as EPS.

Do not submit figures in the following formats: JPEG, GIF, Word, Excel, Lotus 1-2-3, PowerPoint, PDF, Corel Draw.

Graphs must show an appropriate grid scale. Each axis must be labeled with both the quantity measured and the unit of measurement. Color figures must be submitted in a CMYK color space. Do not submit files as RGB.


Tables should not be embedded in the text, but should be included as separate files. A short descriptive title should appear above each table with a clear legend and any footnotes suitably identified below. All units must be included. Figures should be completely labeled, taking into account necessary size reduction. Captions should be entered in the spaces provided.

Spelling and Grammar

All manuscripts must be submitted in English and should be as concise as possible. Either standard American spelling and grammar or standard British spelling and grammar are acceptable, but each manuscript must conform to only one of the two styles. Merriam Webster’s Collegiate Dictionary (10th ed.) should be followed for matters of standard American (English) spelling, compound words, and word division. The Concise Oxford Dictionary of Current English (Clarendon Press, Oxford) should be followed for questions of British (English) spelling and grammar.

Production Process

All material accepted for publication is subject to copyediting. Authors will receive page proofs of articles before publication, and should answer all queries and carefully check all editorial changes at this stage. Authors are asked to check for misprints or syntactic errors and not to otherwise revise the manuscript.


Once a corrected proof is received by the publisher from the author and reviewed with the Editor, individual articles are published on-line in the EarlyView service maintained by the publisher. This makes articles available before they are placed into an issue and reduces publication time to about 2 months. Articles are available as HTML full-text, and each article includes a digital object identifier (DOI) and a collaborative reference linking service through which readers can click on a reference citation and immediately access article content. Once articles are published electronically, it is not possible for authors to make further changes before issue in which it appears is posted.


One set of proofs will be sent to the corresponding author in form of a PDF file. Changes made at this time should reflect corrections of typographical or factual errors. Due to the rapid publication of this journal, proofs must be carefully checked and returned within 48 hours of receipt. Articles will be added to an issue in the order that the publisher receives the proofs. Failure to return proofs within 48 hours may result in the article being delayed for publication until a later issue.


Reprints may be purchased at

Availability of Materials

As a condition of publication in BioFactors, authors must agree to make every reasonable effort to provide colleagues in academic research with any of the cell lines, antibodies, nucleic acids, and other related materials used in the research reported that are not freely available from commercial sources. Nucleic acid sequences, protein sequences, and X-ray crystallographic coordinates must be deposited in the appropriate databases prior to the publication of an article.

Ethics of Experimentation

Contributors are expected to conform to accepted international standards of animal and human experimentation, and to provide evidence of institutional review and approval of animal and human experimental protocols. In cases of dispute, the currently accepted IUBMB guidelines will be followed.


If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the non-standard CTA

If the OnlineOpen option is not selected the corresponding author will be presented with the BioFactors non-standard CTA to sign. The terms and conditions of the non-standard CTA can be previewed below:

Terms and Conditions. Please do not complete this PDF until you are prompted to login into Author Services as described above.

Note to Contributors on Deposit of Accepted Version

Funder arrangements

Certain funders, including the NIH, members of the Research Councils UK (RCUK) and Wellcome Trust require deposit of the Accepted Version in a repository after an embargo period. Details of funding arrangements are set out at the following website: Please contact the Journal production editor if you have additional funding requirements.


Wiley has arrangements with certain academic institutions to permit the deposit of the Accepted Version in the institutional repository after an embargo period. Details of such arrangements are set out at the following website:

For authors choosing OnlineOpen

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution License OAA

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

Authors are themselves responsible for obtaining permission to reproduce copyright material from other sources.

Note to NIH Grantees

Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see


Mangiferin special issue banner

About the Editor

Angelo Azzi

Weizmann Institute of Science

BIOF Young Investigator Award

Carmen Crespo.jpg

On behalf of the IUBMB, BioFactors and Wiley, it is with great pleasure and honor that we announce M. Carmen Crespo as the co-winner of the 2017 BioFactors - Wiley Young Investigator Award for her article, Hydroxytyrosol restores proper insulin signaling in an astrocytic model of Alzheimer's disease.

Eduardo Molina Jijon.jpg
On behalf of the IUBMB, BioFactors and Wiley, it is with great pleasure and honor that we announce Eduardo Molina-Jijón as the co-winner of the 2017 BioFactors - Wiley Young Investigator Award for his article, The nephroprotection exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy.

More on the winners and the Award here.