Volume 18, Issue 1-4 p. 91-100
Article

Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure

Franklin Rosenfeldt

Corresponding Author

Franklin Rosenfeldt

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

Department of Clinical Pharmacology, Alfred Hospital, Melbourne, Victoria, Australia

Assoc. Prof. Franklin Rosenfeldt, Department of Cardiothoracic Surgery, The Alfred Hospital, PO Box 315, Prahran, Victoria 3181, Australia. Tel.: +61 3 9276 3684; Fax: +61 3 9276 2317; E-mail: [email protected]Search for more papers by this author
Deborah Hilton

Deborah Hilton

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

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Salvatore Pepe

Salvatore Pepe

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

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Henry Krum

Henry Krum

Department of Clinical Pharmacology, Alfred Hospital, Melbourne, Victoria, Australia

Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia

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First published: 16 December 2008
Citations: 97

Abstract

Coenzyme Q10 in physical exercise. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect.

CoQ10 in hypertension. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension.

CoQ10 in heart failure. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time.

Meta-analysis of randomised trials of coenzyme Q10 in heart failure. In nine randomised trials of CoQ10 in heart failure published up to 2003 there were non-significant trends towards increased ejection fraction and reduced mortality. There were insufficient numbers of patients for meaningful results. To make more definitive conclusions regarding the effect of CoQ10 in cardiac failure we recommend a prospective, randomised trial with 200–300 patients per study group. Further trials of CoQ10 in physical exercise and in hypertension are recommended.