Review Article
Vitamin E in aging, dementia, and Alzheimer's disease
Yash B. Joshi,
Domenico Praticò,
Yash B. Joshi
Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA, USA
Search for more papers by this authorCorresponding Author
Domenico Praticò
Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA, USA
Tel.: +215-707-9380; Fax: +215-707-7068.
MD, Department of Pharmacology, MRB 706A, 3420 North Broad street, Philadelphia, PA 19140, USASearch for more papers by this authorYash B. Joshi,
Domenico Praticò,
Yash B. Joshi
Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA, USA
Search for more papers by this authorCorresponding Author
Domenico Praticò
Department of Pharmacology, Temple University, School of Medicine, Philadelphia, PA, USA
Tel.: +215-707-9380; Fax: +215-707-7068.
MD, Department of Pharmacology, MRB 706A, 3420 North Broad street, Philadelphia, PA 19140, USASearch for more papers by this authorAbstract
Since its discovery, vitamin E has been extensively researched by a large number of investigators in an attempt to fully understand its role in a variety of pathophysiological contexts. The vast majority of published work has focused on vitamin E's antioxidant properties, which is why it is well known as a lipophilic antioxidant that protects membranes from being oxidatively damaged by free radicals. However, several lines of investigation have recently revealed that vitamin E has biological roles unrelated to its antioxidant properties. Among these roles, vitamin E has been described as: a regulator of signal transduction, gene expression, and redox sensor. In parallel with the discovery of novels cellular functions of vitamin E, the introduction of the free radical theory of brain aging has propelled a renewed interest in this vitamin. Most of the resulting work has been based on the postulate that, by preventing and/or minimizing the oxidative stress-dependent brain damage, vitamin E could be used as therapeutic approach. In this article, we will consider the existing literature regarding the biological properties of vitamin E and the potential therapeutic and/or preventative roles that this natural dietary factor plays in brain aging, cognition, and Alzheimer's dementia. © 2012 International Union of Biochemistry and Molecular Biology, Inc.
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