Virgin olive oil and coenzyme Q10 protect heart mitochondria from peroxidative damage during aging
Corresponding Author
J. R. Huertas
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Department of Physiology, Faculty of Pharmacy, Granada University, 18071-Granada, SpainSearch for more papers by this authorE. Martinez-Velasco
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorS. Ibáñez
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorM. López-Frias
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorJ. J. Ochoa
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorJ. Quiles
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorG. Parenti Castelli
Department of Biochemistry “G. Moruzzi”, University of Bologna, 40126 Bologna, Italy
Search for more papers by this authorJ. Mataix
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorG. Lenaz
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorCorresponding Author
J. R. Huertas
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Department of Physiology, Faculty of Pharmacy, Granada University, 18071-Granada, SpainSearch for more papers by this authorE. Martinez-Velasco
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorS. Ibáñez
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorM. López-Frias
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorJ. J. Ochoa
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorJ. Quiles
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorG. Parenti Castelli
Department of Biochemistry “G. Moruzzi”, University of Bologna, 40126 Bologna, Italy
Search for more papers by this authorJ. Mataix
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorG. Lenaz
Department of Physiology, Nutrition Institute and Food Technology, University of Granada, 18071-Granada, Spain
Search for more papers by this authorAbstract
The mitochondrial theory of aging suggests that this phenomenon is the consequence of random somatic mutations in mitochondrial DNA, induced by long-term exposure to free radical attack. There are two potential dietary means of delaying the effects of free radicals on cellular aging, i.e., enrichment of mitochondrial membranes with monounsaturated fatty acids and supplementation with antioxidants. We have performed a preliminary study on male rats, 6 or 12 month old, fed with diets differing in the nature of the fat (virgin olive oil or sunflower oil) and/or with antioxidant supplementation (coenzyme Q10), analysing hydroperoxide and coenzyme Q9 and Q10 in heart mitochondria. Preliminary results allow us to conclude that the CoQ10 dietetic supplementation as well as the enrichment of the cellular membranes with monounsaturated fatty acids, successfully protect mitochondrial membranes from aged rats against the free radical insult.
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