On the Cover: lncRNAs mechanisms of action: As a scaffold aids in the assembly of RNA protein complexes, thereby facilitating or inhibiting transcription. (B) As a signal molecule recruits chromatin modification enzymes such as deacetylases, acetylases, and histone methylases in response to varying stimuli to suppress locus genes. (C) LncRNAs sponge miRNAs to repress miRNA-mediated gene regulation. (D) As a guide from transcription complexes to control the expression of downstream genes. (E) Decoy lncRNAs prevent the binding of regulatory factors to the genome and terminate its regulation. (F) Upon binding to RBPs, and changing their cellular localization which in turn alters the expression of RBPs target genes by Ebrahimnezhad et al.; Article first published: 1 August 2024; https://doi.org/10.1002/iub.2888.